Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Identifieur interne : 005780 ( Main/Exploration ); précédent : 005779; suivant : 005781Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Auteurs : Hossam Murad [France] ; Philippe Collet [France] ; Cecile Huin-Schohn [France] ; Nehmann Al-Makdissy [France] ; Geraldine Kerjan [France] ; Alain Chedotal [France] ; Mireille Donner [France] ; Marie-Dominique Devignes [France] ; Philippe Becuwe [France] ; Hervé Schohn [France] ; Lionel Domenjoud [France] ; Michel Dauça [France]Source :
English descriptors
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Abstract
This study tests the hypothesis that the activators of peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. The human MCF-7 breast adenocarcinoma cell line was chosen because it expresses Sema6B at a high level. The Sema 6B mRNA level was analysed by RT-PCR and the semaphorin 6B protein content was determined using a polyclonal antibody that we have produced and characterized. Treatments with fenofibrate (a PPAR alpha activator) and troglitazone (a PPARgamma ligand) strongly decreased the Sema6B mRNA. The drop in Sema 6B mRNA level and in protein content was more important when the treatment combined the action of fenofibrate or troglitazone and 9-cis-retinoic aid. On the other hand, no significant change was observed in the Sema 6B mRNA and protein levels when the cells were exposed to the combined action of GW610742 (a PPARbeta activator) and 9-cis-retinoic acid. These data suggest that PPARalpha/RXR and PPARgamma/RXR heterodimers are involved in the regulation of Sema6B gene expression and open new perspectives concerning the participation of these nuclear receptors in cell recognition and migration.
Url:
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy
- Institut national polytechnique de Lorraine, Université Nancy 2, Université de Lorraine
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Le document en format XML
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B , 4è, 5è, 6è étages 9 Quai Saint-Bernard - BP case1 75252 PARIS CEDEX 05</addrLine><country key="FR"></country></address><ref type="url">http://npa.snv.jussieu.fr</ref></desc><listRelation><relation active="#struct-93591" type="direct"></relation><relation name="UMR7102" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName><orgName type="acronym">UPMC</orgName><desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.upmc.fr/</ref></desc></org></tutelle><tutelle name="UMR7102" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Donner, Mireille" sort="Donner, Mireille" uniqKey="Donner M" first="Mireille" last="Donner">Mireille Donner</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-21456" status="INCOMING"><orgName>Proliférateurs des Peroxysomes - 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BP 10578153 Le Chesnay Cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.inria.fr/en/</ref></desc></org></tutelle><tutelle active="#struct-300291" type="indirect"><org type="institution" xml:id="struct-300291" status="OLD"><orgName>Université Henri Poincaré - Nancy 1</orgName><orgName type="acronym">UHP</orgName><date type="end">2011-12-31</date><desc><address><addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300292" type="indirect"><org type="institution" xml:id="struct-300292" status="OLD"><orgName>Université Nancy 2</orgName><date type="end">2011-12-31</date><desc><address><addrLine>91 avenue de la Libération, BP 454, 54001 Nancy cedex</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300293" type="indirect"><org type="institution" xml:id="struct-300293" status="OLD"><orgName>Institut National Polytechnique de Lorraine</orgName><orgName type="acronym">INPL</orgName><date type="end">2011-12-31</date><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-2496" type="direct"><org type="laboratory" xml:id="struct-2496" status="OLD"><orgName>INRIA Lorraine</orgName><desc><address><addrLine>615 rue du Jardin Botanique 54600 Villers-lès-Nancy</addrLine><country key="FR"></country></address><ref type="url">http://www.inria.fr/centre-de-recherche-inria/nancy-grand-est</ref></desc><listRelation><relation active="#struct-300009" type="direct"></relation></listRelation></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName><orgName type="university">Université Nancy 2</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lorraine</orgName><placeName><settlement type="city">Nancy</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName><orgName type="university">Institut national polytechnique de Lorraine</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Becuwe, Philippe" sort="Becuwe, Philippe" uniqKey="Becuwe P" first="Philippe" last="Becuwe">Philippe Becuwe</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-21456" status="INCOMING"><orgName>Proliférateurs des Peroxysomes - EA3446</orgName><desc><address><addrLine>Faculty of Sciences, BP239, 54506 Vandoeuvre-les-Nancy cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300291" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300291" type="direct"><org type="institution" xml:id="struct-300291" status="OLD"><orgName>Université Henri Poincaré - Nancy 1</orgName><orgName type="acronym">UHP</orgName><date type="end">2011-12-31</date><desc><address><addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Schohn, Herve" sort="Schohn, Herve" uniqKey="Schohn H" first="Hervé" last="Schohn">Hervé Schohn</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-21456" status="INCOMING"><orgName>Proliférateurs des Peroxysomes - EA3446</orgName><desc><address><addrLine>Faculty of Sciences, BP239, 54506 Vandoeuvre-les-Nancy cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300291" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300291" type="direct"><org type="institution" xml:id="struct-300291" status="OLD"><orgName>Université Henri Poincaré - Nancy 1</orgName><orgName type="acronym">UHP</orgName><date type="end">2011-12-31</date><desc><address><addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Domenjoud, Lionel" sort="Domenjoud, Lionel" uniqKey="Domenjoud L" first="Lionel" last="Domenjoud">Lionel Domenjoud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-21456" status="INCOMING"><orgName>Proliférateurs des Peroxysomes - EA3446</orgName><desc><address><addrLine>Faculty of Sciences, BP239, 54506 Vandoeuvre-les-Nancy cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300291" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300291" type="direct"><org type="institution" xml:id="struct-300291" status="OLD"><orgName>Université Henri Poincaré - Nancy 1</orgName><orgName type="acronym">UHP</orgName><date type="end">2011-12-31</date><desc><address><addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dauca, Michel" sort="Dauca, Michel" uniqKey="Dauca M" first="Michel" last="Dauça">Michel Dauça</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-21456" status="INCOMING"><orgName>Proliférateurs des Peroxysomes - EA3446</orgName><desc><address><addrLine>Faculty of Sciences, BP239, 54506 Vandoeuvre-les-Nancy cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300291" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300291" type="direct"><org type="institution" xml:id="struct-300291" status="OLD"><orgName>Université Henri Poincaré - Nancy 1</orgName><orgName type="acronym">UHP</orgName><date type="end">2011-12-31</date><desc><address><addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>9-cis-retinoic acid receptor</term><term>MCF-7cells</term><term>peroxisome proliferator</term><term>peroxisome proliferator-activated receptor</term><term>semaphorin 6B</term><term>semaphorins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study tests the hypothesis that the activators of peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. The human MCF-7 breast adenocarcinoma cell line was chosen because it expresses Sema6B at a high level. The Sema 6B mRNA level was analysed by RT-PCR and the semaphorin 6B protein content was determined using a polyclonal antibody that we have produced and characterized. Treatments with fenofibrate (a PPAR alpha activator) and troglitazone (a PPARgamma ligand) strongly decreased the Sema6B mRNA. The drop in Sema 6B mRNA level and in protein content was more important when the treatment combined the action of fenofibrate or troglitazone and 9-cis-retinoic aid. On the other hand, no significant change was observed in the Sema 6B mRNA and protein levels when the cells were exposed to the combined action of GW610742 (a PPARbeta activator) and 9-cis-retinoic acid. These data suggest that PPARalpha/RXR and PPARgamma/RXR heterodimers are involved in the regulation of Sema6B gene expression and open new perspectives concerning the participation of these nuclear receptors in cell recognition and migration.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Nancy</li></settlement><orgName><li>Institut national polytechnique de Lorraine</li><li>Université Nancy 2</li><li>Université de Lorraine</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Murad, Hossam" sort="Murad, Hossam" uniqKey="Murad H" first="Hossam" last="Murad">Hossam Murad</name></noRegion><name sortKey="Al Makdissy, Nehmann" sort="Al Makdissy, Nehmann" uniqKey="Al Makdissy N" first="Nehmann" last="Al-Makdissy">Nehmann Al-Makdissy</name><name sortKey="Becuwe, Philippe" sort="Becuwe, Philippe" uniqKey="Becuwe P" first="Philippe" last="Becuwe">Philippe Becuwe</name><name sortKey="Chedotal, Alain" sort="Chedotal, Alain" uniqKey="Chedotal A" first="Alain" last="Chedotal">Alain Chedotal</name><name sortKey="Collet, Philippe" sort="Collet, Philippe" uniqKey="Collet P" first="Philippe" last="Collet">Philippe Collet</name><name sortKey="Dauca, Michel" sort="Dauca, Michel" uniqKey="Dauca M" first="Michel" last="Dauça">Michel Dauça</name><name sortKey="Devignes, Marie Dominique" sort="Devignes, Marie Dominique" uniqKey="Devignes M" first="Marie-Dominique" last="Devignes">Marie-Dominique Devignes</name><name sortKey="Domenjoud, Lionel" sort="Domenjoud, Lionel" uniqKey="Domenjoud L" first="Lionel" last="Domenjoud">Lionel Domenjoud</name><name sortKey="Donner, Mireille" sort="Donner, Mireille" uniqKey="Donner M" first="Mireille" last="Donner">Mireille Donner</name><name sortKey="Huin Schohn, Cecile" sort="Huin Schohn, Cecile" uniqKey="Huin Schohn C" first="Cecile" last="Huin-Schohn">Cecile Huin-Schohn</name><name sortKey="Kerjan, Geraldine" sort="Kerjan, Geraldine" uniqKey="Kerjan G" first="Geraldine" last="Kerjan">Geraldine Kerjan</name><name sortKey="Schohn, Herve" sort="Schohn, Herve" uniqKey="Schohn H" first="Hervé" last="Schohn">Hervé Schohn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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